Pulmonary tuberculosis and sepsis
Conditions
Interventions
Experimental group:Cytokine adsorption therapy+conventional treatment
Control group:Conventional treatment
Sponsors
Guangzhou Chest Hospital (tuberculosis Prevention and Control Institute, tuberculosis Treatment Center)
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: Age range from 18 to 75 years old; Meets the following three criteria: ? Confirmed pulmonary tuberculosis patients: Diagnosis and Treatment Guidelines for Pulmonary Tuberculosis (2013 Edition); ? Respiratory failure: in accordance with the Clinical Guidelines for Mechanical Ventilation (2006); ? Sepsis: 2016 Sepsis 3.0 standard: presence of infection with two or more of the following symptoms: body temperature>38.3 ° C or90 beats per minute; Rapid breathing>20 beats per minute or arterial partial pressure of carbon dioxide (PaCO 2)7.7 mmol/L [>140 mg/dL]); Acute changes in consciousness state; Increased white blood cells (white blood cell, WBC count>12) × 10 ?/L [12000/ µ L] ); Decreased white blood cells (WBC count10%.
Exclusion criteria
Exclusion criteria: Pregnant women with respiratory failure induced by bronchial asthma, common obstructive airway diseases (such as COPD), bronchiectasis, severe heart disease, and contraindications to mechanical ventilation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 28 day survival rate; ICU ICU survival rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hemodynamic parameters (dose of vasopressor);72 hour post body fluid balance and pre - and post intervention organ failure assessment score (SOFA); | — |
Countries
China
Contacts
Public ContactHu Jinxing
Guangzhou Chest Hospital (tuberculosis Prevention and Control Institute, tuberculosis Treatment Center)
Outcome results
None listed