kidney transplant
Conditions
Interventions
Group D:Dexmedetomidine group received intraoperative pump infusion of dexmedetomidine at a rate of 0.2ug/kg/h, and the pump infusion was stopped 30 minutes before the end of surgery, with a total amo
Group C:The control group received general anesthesia and began pumping physiological saline after anesthesia induction. The pumping was stopped 30 minutes before the end of the surgery.
Group M:Midazolam group received intraoperative pump infusion of Midazolam at a rate of 0.02mg/kg/h, and the pump infusion was stopped 30 minutes before the end of surgery, with a total amount not exc
Sponsors
The Second Xiangya Hospital of Central South University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: ? Patients who undergo elective kidney transplantation surgery due to end-stage renal disease; ? Age range from 18 to 65 years old; ? ASA level I-III; ? Patients who voluntarily participate in this study and obtain informed consent.
Exclusion criteria
Exclusion criteria: ? Known intolerance or allergy to dexmedetomidine; ? Mental illness patients; ? Severe heart, liver, and lung dysfunction; ? Accompanied by sinus bradycardia (heart rate below 60 beats per minute and/or positive atropine stimulation test), II or III degree atrioventricular block, and pathological sinus node syndrome; ? Preoperative hypotension (SBP<120mmHg) cannot be corrected even after 250ml fluid replacement; ? Previous history of cerebrovascular or central nervous system diseases; ? Patients who cannot cooperate for other reasons.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of emergence agitation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Wake-up time;Extubation time;PACU stay time;Postoperative Pain;Postoperative sleep;Postoperative renal function; | — |
Countries
China
Contacts
Public ContactJiang Xinghua
The Second Xiangya Hospital of Central South University
Outcome results
None listed