oxaliplatin-induced peripheral neuropathy
Conditions
Interventions
Warm Acupuncture Group:The patient took a prone position to fully expose the acupuncture and moxibustion position. Doctors Use 75% alcohol to locally disinfect the acupuncture site, with acupoints inc
Usual Care Group:Advise participants to avoid contact with cold and hot water
Wear gloves and outer socks to protect hands and feet and avoid direct contact with metal objects
Prohibition of drinking alcohol
Avoid hiking exercises.
Sponsors
Jiangsu Provincial Hospital of Integrated Chinese and Western Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: (1) All cases were confirmed by histopathological evidence as intestinal malignant tumors; (2) Age 18-85 years old; (3) Chemotherapy with mFOLFOX6 or XELOX regimen, and 3 months after completion =of chemotherapy; (4) Patients with peripheral neuropathy after chemotherapy, NCI CTCAE version 4.0 neurotoxicity classification = grade 2; (5) Those who do not have serious damage to the heart, liver, kidney or hematopoietic system, or who have abnormalities but meet the enrollment requirements after symptomatic treatment (such as whitening, platelet promotion, liver protection, etc.); (6) Patients with a Karl Fischer score of 60 or more are expected to survive = 6 months; (7) No intellectual or mental disorders, normal language skills, and the ability to judge their own feelings and general conditions; (8) Voluntarily participate in the trial and give informed consent.
Exclusion criteria
Exclusion criteria: (1) Peripheral neuropathy caused by other reasons, such as diabetes, infection, radiotherapy, poisoning, etc., or the patient originally suffered from peripheral paresthesia and nervous system abnormalities. and those who are receiving other drugs with neurotoxicity; (2) Patients with severe heart, liver and kidney insufficiency; (3) Pregnant and lactating women; (4) Those who are accompanied by mental and mental disorders and cannot cooperate; (5) Severe skin diseases or broken skin of the limbs; (6) Received acupuncture treatment for any indication within the past month.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| NCI-CTCAE4.0 Neurotoxicity Grading;EORTC QLQ-C30 Quality of Life Rating Scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| EORTC QLQ-CIPN20 Tablet; | — |
Countries
China
Contacts
Public ContactHuo Jiege
Jiangsu Provincial Hospital of Integrated Chinese and Western Medicine
Outcome results
None listed