septic shock
Conditions
Interventions
2groups:Pituitrin (2u/h intravenously pumped)
Sponsors
Northern Jiangsu People’s Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Each patient must meet all of the following inclusion criteria in order to be included in the study: (1) Adult patients with refractory septic shock aged = 18 years are defined as those who require a total dose of norepinephrine of = 0.5 µ g/kg/min (converted to norepinephrine equivalent as shown in Table 1) to maintain mean arterial pressure (MAP) between 55-70 mmHg for a period of no more than 6 hours. (2) The patient has placed a central venous catheter and undergone invasive blood pressure monitoring, which has been present for at least the first 48 hours of the study. (3) The patient must receive at least 25mL/kg of crystal or colloid equivalent within the first 24 hours and undergo sufficient fluid resuscitation according to the opinion of the treatment researcher. (4) Patients must meet the diagnostic criteria for septic shock, which include persistent hypotension after sufficient volume resuscitation, the need for vasoactive drugs to maintain mean arterial pressure (MAP) = 65 mmHg, and serum lactate levels>2 mmol/L. (5) The patient or legal representative is willing and able to provide written informed consent and comply with all protocol requirements.
Exclusion criteria
Exclusion criteria: Patients who meet any of the following exclusion criteria are not eligible for inclusion in the study: (1) Patients under 18 years old. (2) Pregnant women (3) Patients with concomitant acute coronary syndrome. (4) Liver failure patients with end-stage liver function child C grading. (5) Patients with acute mesenteric ischemia or a history of mesenteric ischemia. (6) Patients with a history of aortic dissection or abdominal aortic aneurysm, with the presence or high suspicion of having aortic dissection or abdominal aortic aneurysm. (7) Patients who require a daily dose of 500 mg or more of hydrocortisone or equivalent glucocorticoid drugs as a routine dose. (8) Patients with Renault's phenomenon, systemic sclerosis, or vascular spasms.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Response of mean arterial pressure at 3 hours after the start of infusion; | — |
Secondary
| Measure | Time frame |
|---|---|
| Time to meet MAP = 65mmHg standard;Equivalent demand for catecholamines;Application time of vasoactive drugs;Lactic acid compliance time;CRRT time;Mechanical ventilation time; | — |
Countries
China
Contacts
Public ContactXiaolan Xu
Northern Jiangsu People’s Hospital
Outcome results
None listed