Reaction during tracheal intubation
Conditions
Interventions
Oliceridine group:Give a certain dose of Oselidine
Sponsors
Chongqing University Fuling Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: ( 1 ) 18 = age = 60 years old, ASA I-II, 18kg / m2 = BMI = 28kg / m2, regardless of gender; ( 2 ) Patients undergoing surgery under general anesthesia with tracheal intubation and mechanical ventilation; ( 3 ) Voluntary signing of informed consent.
Exclusion criteria
Exclusion criteria: ( 1 ) Known to be allergic to the study drug or belong to the susceptible population; ( 2 ) There are contraindications to general anesthesia; ( 3 ) Suffering from serious heart, cerebrovascular disease, respiratory disease, blood disease, endocrine disease or liver and kidney dysfunction; ( 4 ) Predictable difficult airway ( Mallampati grade III or IV ) or high risk factors for difficult laryngoscope exposure and difficult intubation: cervical disease, tooth abnormality, small jaw, mouth opening < 3 fingers, sleep apnea syndrome and snoring history, upper respiratory disease symptoms, subglottic stenosis, thyroid or tonsil enlargement, mediastinal mass, throat tumor, etc.; ( 5 ) Surgery or use of experimental drugs within one week before surgery; ( 6 ) Communication disorders, including reading and writing Chinese barriers, language barrier, visual impairment or hearing impairment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Reaction during tracheal intubation; | — |
Secondary
| Measure | Time frame |
|---|---|
| The incidence of propofol injection pain;Induction period cough incidence rate;The incidence of coughing during awakening;Pain score;Wake-up time;Adverse reaction incidence rate; | — |
Countries
China
Contacts
Public ContactHe Keyu
Chongqing University Fuling Hospital
Outcome results
None listed