Cognitive impairment in the elderly
Conditions
Interventions
subjective cognitive decline(SCD)group:None
mild cognitive impairment(MCI)group:None
Sponsors
The First Affiliated Hospital of Nanjing Medical University/Jiangsu Provincial People's Hospital
Eligibility
Sex/Gender
All
Age
55 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) MCI group: one of the following three conditions must be met: (i) scores on two neuropsychological assessments in at least one cognitive domain (memory, language, or executive function) are below 1.0 standard deviation (SD); (ii) scores on one neuropsychological assessment in each of the three cognitive domains (memory, language, or executive function) are below 1.0 SD; or (iii) scores on the Functional Assessment Questionnaire (FAD) are =9. The SD-based thresholds used in this study refer to published studies on Chinese populations and have been adjusted for education and age. (2) SCD group: (i) did not meet the above neuropsychological criteria for the diagnosis of MCI; (ii) complained of persistent memory decline in the last 6 months compared to the previous normal state, which was not related to an acute event; and (iii) self-reported concerns about memory decline. (3) HC group: (i) no self-experienced persistent memory decline and memory loss; (ii) scores >26 on the Brief Mental State Exercise (MMSE) and >26 on the Montreal Cognitive Assessment Scale (MoCA); and (iii) 0 on the Clinical Dementia Rating Scale (CDR).
Exclusion criteria
Exclusion criteria: Exclusion criteria: ? Meet the diagnostic criteria of vascular dementia formulated by the National Institute of Neurological Disorders and Stroke and the Swiss International Association for Neuroscience Research (NINDS-AIREN); ? Score of >4 on the Modified Hachinski Ischemia Scale; ? Cannot cooperate with the cognitive function test (including blindness, deafness, severe language disorders, etc.); ? Drug or alcohol dependence in the last 6 months; ? Being Participating in other clinical studies; ? Combined serious cardiovascular disease, cerebrovascular disease, liver disease, renal disease and psychiatric disorders; ? Age greater than 80 years old and less than 55 years old; ? Non-dextrocardiac hand, verified by the Edinburgh Habitual Hand Scale; ? Geriatric depression scale score = 6; ? Taking cognitive improvement drugs or psychoactive drugs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of sticks inserted and removed to complete the nine-hole peg test in 30 seconds time; | — |
Secondary
| Measure | Time frame |
|---|---|
| mini-mental state examination, MMSE;Montreal cognitive assessment,MoCA;Auditory Verbal Learning Test-Huashan version (AVLT-H);Boston Naming Test China version(BNT-C);Animal Fluency test;Shape Trail Test-A China version(STT-A-C);Shape Trail Test-B China version(STT-B-C);Functional near-infrared imaging of resting-state brain connectivity;Brain activation during execution of the nine-hole peg test in functional near-infrared imaging; | — |
Countries
China
Contacts
Public ContactShen Ying
The First Affiliated Hospital of Nanjing Medical University/Jiangsu Provincial People's Hospital
Outcome results
None listed