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The effect of PAD4 inhibitor mediated downregulation of NETs on preeclampsia

The effect of PAD4 inhibitor mediated downregulation of NETs on preeclampsia

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2400082408
Enrollment
Unknown
Registered
2024-03-28
Start date
2024-04-01
Completion date
Unknown
Last updated
2024-04-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Severe preeclampsia

Interventions

Sponsors

Nanjing Women and Children's Hospital
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 45 Years

Inclusion criteria

Inclusion criteria: Selection criteria: Healthy volunteers who are not pregnant; Age = 18 years old; Agree to participate and sign an informed consent form. Pregnant women with normal pregnancy: Pregnant women aged = 18 years old; Agree to participate and sign an informed consent form. Pregnant women who have developed preeclampsia: Pregnant women aged = 18 who have developed preeclampsia; Agree to participate and sign an informed consent form.

Exclusion criteria

Exclusion criteria: Exclusion criteria: Unpregnant healthy volunteers: Pregnant and postpartum (within 3 months after delivery), any history of thrombotic events, chronic diseases, chronic or recent infections, and cancer. The exclusion criteria for pregnant women with normal pregnancy are: any previous pregnancy complications caused by the placenta, any history of thrombotic events, chronic diseases, chronic or recent infections, and cancer. Pregnant women who have developed preeclampsia: any history of thrombotic events, chronic diseases, chronic or recent infections, and cancer.

Design outcomes

Primary

MeasureTime frame
mean arterial pressure;Urine protein; creatinine;Glomerular filtration rate;C-reactive protein;Procalcitonin;IL-6;CitH3;myloperoxidase;PAD4;

Secondary

MeasureTime frame
blood pressure;Age;Past medical history;Smoking habits;

Countries

China

Contacts

Public ContactFengchan Xi

Nanjing Women and Children's Hospital

xifengchan@aliyun.com+86 138 1308 8919

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026