Advanced solid tumors
Conditions
Interventions
test group:Trilaciclib combined with chemotherapy
Sponsors
Department of Thoracic Oncology, Cancer Center, Bethune Hospital, Shanxi
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Signed written informed consent before enrollment; 2. Aged > 18 years old, male or female; 3. Pathological examination confirmed the diagnosis of malignant tumors, chemotherapy-based treatment is required, and first-line treatment; 4. ECOG score = 0 points, expected survival = 3 months, follow-up observation for more than 3 months; 5. Blood routine, liver and kidney function, myocardial enzymes and ECG showed no significant abnormalities; 6. Subjects voluntarily joined this study, good compliance, with safety and survival follow-up.
Exclusion criteria
Exclusion criteria: 1. allergic to biological agents; 2. received any cytotoxic chemotherapy or PD-1/PD-L1 inhibitor treatment = 14 days before the first dose of study drug (if relevant); 3. received any study drug = 30 days or = half-life (whichever is longer) before the first dose of study drug; 4. had poor healing factors such as edema, ischemia, and tension at the anastomotic stoma; 5. complete intestinal obstruction; 6. severe cardiovascular disease; 7. infectious disease; 8. bleeding tendency or coagulation dysfunction; 9. unstable vital signs; 10. cachexia; 1.the investigator believes that it should be excluded from this study, for example, in the investigator 's judgment, the subject has other factors that may force the study to terminate halfway, such as other serious diseases (including mental illness) requiring concomitant treatment, severe laboratory abnormalities, accompanied by family or social factors, which will affect the safety of the subject, or the collection of data and samples
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of SN;Incidence of FN; | — |
Secondary
| Measure | Time frame |
|---|---|
| ORR;Bone marrow protection ; | — |
Countries
China
Contacts
Public ContactHuijing Feng
Shanxi Bethune Hospital
Outcome results
None listed