Talaromycosis
Conditions
Interventions
Liposome amphotericin B group (observed group):Induction period receiving treatment with liposomes amphotericin B
Amphotericin B deoxycholate group (control group):Induction period receiving treatment with Amphotericin B deoxycholate
Sponsors
The Fourth People's Hospital of Nanning
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Age = 18 years old; 2. Confirmed HIV infection; 3.Diagnosis of Talaromyces marneffei infection, diagnostic criteria: ? Clinical syndromes with Talaromyces marneffei infection (fever, emaciation, anemia, lymph node enlargement, Liver and spleen enlargement, etc); ? Confirmed Talaromyces marneffei infection through blood culture; or ?Clinical blood samples show positive of Talaromyces marneffei by polymerase chain reaction (PCR);
Exclusion criteria
Exclusion criteria: 1. Pregnant or lactating female patients; 2. Liver dysfunction (baseline ALT and AST greater than 5 times the upper limit of normal values); 3. Severe renal insufficiency or the need for hemodialysis (creatinine clearance rate less than 30); 4. Co-infection with other systemic fungal infections with clear diagnostic evidence (cryptococcal, candidaemia, or mucor infection); 5. Patient diagnosed with tuberculosis and undergoing anti-tuberculosis treatment; 6. Paitent with mental illness or abnormal behavior; 7. Receive systemic antifungal therapy for 48 hours or more before enrollment; 8. Current participants in other clinical trials; 9. The researcher assessed that there are other factors not suitable for inclusion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical response rate at day 14; | — |
Secondary
| Measure | Time frame |
|---|---|
| All-cause mortality at day 14;Adverse events on day 14;Recurrence of Talaromyces marneffei infection;Incidence of immune reconstitution inflammatory syndrome (IRIS); | — |
Countries
China
Contacts
Public ContactJun Zou
The Fourth People's Hospital of Nanning, Changqian Road, Xingning District, Nanning City, Guangxi Province
Outcome results
None listed