Brain injury complicated with hypernatremia
Conditions
Interventions
Early treatment group:The early treatment group started CRRT treatment immediately after randomization.
Standard treatment group:After randomization, CRRT indications appear or blood sodium exceeds 170mmol/L, and CRRT treatment is started.
Sponsors
The First Affiliated Hospital of the Air Force Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Age =18 years old; 2. Diagnosis of brain injury, including: ? acute intracranial hemorrhage (such as intracerebral hemorrhage, subdural hematoma, epidural hematoma, etc.); ? Ischemic stroke (cerebral infarction); ? Mild to moderate traumatic brain injury (open or closed); ? Determine the types of brain tumors (such as gliomas and meningiomas); 3. Acute moderate and severe hypernatremia; 4. Patient/legal representative/legal supervisor Guardian/family members sign informed consent form.
Exclusion criteria
Exclusion criteria: 1. Low volume hypernatremia; 2. Pregnancy or breast-feeding period; 3. Previous chronic kidney disease (EGFR < 30 ml/min); Patients who have participated in clinical trials of other drugs/devices within 4.3 months; 5. The estimated survival time is less than 72 hours, or the clinical condition is not expected to be stable within 72 hours; 6. Severe heart, liver, lung or other important organ dysfunction, which may affect the test results or patient safety; 7. Any other illness or condition that the researcher thinks is not suitable to participate in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 28-day survival rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Nerve function recovery;High sodium Correction of anemia;24h osmotic demyelination; | — |
Countries
China
Contacts
Public ContactMing Bai
The First Affiliated Hospital of the Air Force Medical University
Outcome results
None listed