Postoperative complications of extubation
Conditions
Interventions
Control Group:Intravenous injection of 5ml saline before extubation in PACU after surgery
Intervention Group A:Intravenous infusion of 0.5-1µg/kg remifentanil(10µg/mL) combined with 1mg neostigmine(0.5mg/mL) and 0.5mg atropine(0.5mg/mL) before extubation in PACU after surgery
Intervention Group B:Intravenous infusion of 0.5-1µg/kg remifentanil(10µg/mL) before extubation in PACU after surgery
Intervention Group C:Intravenous infusion of1mg neostigmine(0.5mg/mL) and 0.5mg atropine(0.5mg/mL) before extubation in PACU after surgery
Sponsors
Anesthesiology Department of Jiangyin Hospital Affiliated to Nantong University
Eligibility
Sex/Gender
All
Age
1 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Perform general anesthesia plan 2. ASA classification: Level I-II 3. Age:<80 years old 4. No history of long-term use of opioid or antipsychotic drugs 5. No history of drug allergy 6. Informed consent
Exclusion criteria
Exclusion criteria: 1. Myasthenia gravis, glaucoma 2. Allergies to various components and opioid drugs of this drug 3. Patient Refusal
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of coughing and adverse reactions during PACU extubation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Extubation time (from intravenous administration of medication in PACU to removal of tracheal catheter);Coughing severity score during extubation;Rating of awakening agitation during extubation;Sedation score after extubation;Heart rate;Blood oxygen saturation;Mean arterial pressure; | — |
Countries
China
Contacts
Public ContactSong Wenxiang
Jiangyin Hospital Affiliated to Nantong University
Outcome results
None listed