Chronic obstructive pulmonary disease
Conditions
Interventions
Sponsors
Qingdao Municipal Hospital
Eligibility
Sex/Gender
All
Age
45 Years to 75 Years
Inclusion criteria
Inclusion criteria: ?COPD diagnosis according to Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria ?Patients with stable moderate-to-severe COPD (FEV1%pred <80% after bronchodilators), without antibiotics and systemic corticosteroids within 4 weeks ?Age 45-75 years, BMI 18-36Kg/m2 ? ability to participate in regular physical activity and absence of other local or systemic diseases affecting exercise such as heart, liver and kidney;
Exclusion criteria
Exclusion criteria: ?Acute onset of COPD within the last 1 month; ? severe cognitive impairment and inability to understand or follow treatment instructions; ?Comorbidity with other severe or unstable illnesses; ? Pulmonary rehabilitation therapy (or other systematic physical training related to the disease) in the last 6 months;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Six-minute walking test distance;Blood inflammatory factors;sputum microbiota;gut microbiota; | — |
Secondary
| Measure | Time frame |
|---|---|
| CAT;Pulmonary function;mMRC; | — |
Countries
China
Contacts
Public ContactHan Wei
Department of Respiratory and Critical Medicine, Qingdao Municipal Hospital, Shinan District, Qingdao, Shandong Province
Outcome results
None listed