HR positive breast cancer
Conditions
Interventions
Test group:After the progression of endocrine therapy: Piperoxili capsule combined with fluvestrant injection.
Without endocrine therapy: Exemestane monotherapy or piperacillin capsules combined with
Sponsors
Taizhou Hospital of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: 1.Age above 18 years old (including 18 years old), regardless of gender.; 2.HR positive breast cancer consistent with pathological diagnosis.; 3.Informed consent, volunteer. The process of obtaining informed consent shall comply with GCP regulations.;
Exclusion criteria
Exclusion criteria: 1.For pregnant and lactating women, the subjects refused to take effective contraceptive methods.; 2.Patients with a history of uncontrolled epilepsy, central nervous system disease, or mental disorders were assessed by the investigator as to whether their clinical severity prevented the signing of informed consent or affected the patient's adherence to oral medications.; 3.Patients who are allergic to any therapeutic drug or its excipient ingredients.; 4.Known human immunodeficiency virus (HIV) infection (known HIV antibody positive).; 5.Inability to swallow, intestinal obstruction, or other factors that affect the taking and absorption of the drug.; 6.In the judgment of the investigator, there is a serious concomitant disease that endangers the patient's safety or interferes with the patient's ability to complete the study (including but not limited to severe high blood pressure that cannot be controlled by the drug, severe diabetes, active infection, etc.).; 7.The patient did not recover from the toxic effects of previous treatment to grade 0-1 (except for hair loss).; 8.The investigator did not consider the patient suitable for participation in any other condition of the study.;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Event-free survival (EFS); | — |
Secondary
| Measure | Time frame |
|---|---|
| Progression-free survival, objective response rate, disease control rate, duration of efficacy;Blood, urine routine, stool routine. Electrocardiogram, Liver function , renal function.; | — |
Countries
China
Contacts
Public ContactChen Qiulan
Taizhou Hospital of Traditional Chinese Medicine
Outcome results
None listed