Analgesic efficacy of low-opioid anesthesia combined with epidural block in lumbar surgery

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2400082300

Enrollment

Unknown

Registered

2024-03-26

Start date

2024-03-26

Completion date

Unknown

Last updated

2024-04-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

pain

Interventions

Opioid-free Group:Dexmedetomidine 0.8ug/kg intravenous drip, epidural placement: the patient is asked to lie on his side, the positioning of the selected surgical site to the cephalic end of the upwar

dexmedetomidine 0.1 mcg/kg/h

magnesium sulfate 5 g to 120 mL, 5 mL/h continuous infusion for 24h, no setting for self-controlled administration. Pump 2: hydromorphone 8 mg + granisetron 2 mg to 150 mL, background dose 0 mL/hr, PC

control group:Dexmedetomidine 0.8ug/kg IV was given 20min before surgery. There was no epidural operation. Intraoperatively, a loading dose of sufentanil 0.5mcg/kg was given after induction, and addit

Eligibility

Sex/Gender

All

Age

18 Years to 85 Years

Inclusion criteria

Inclusion criteria: ? Age: 18-85 years old ? Patients with spinal spondylolisthesis and other serious spinal diseases, non-surgical treatment is ineffective. Patients evaluated by orthopedic surgeons for lumbar single or multiple segment (within 3 segments) decompression through intervertebral foramina for internal fixation were suitable and selected for posterior median incision ?BMI 18-32 ? Gender unlimited ? Volunteer to participate in this clinical investigator

Exclusion criteria

Exclusion criteria: Liver Insufficiency ? renal insufficiency ?Tuberculosis or tumor of the spine ?Central nervous system disease, mental disease ? Spinal deformity or trauma (vi) Infection near the puncture site (vii) Coagulation insufficiency (8) Preoperative bradycardia with atrioventricular block (2nd or 3rd degree), long-term ß-blocker therapy and QT prolongation drug therapy. Patients who have been evaluated by orthopedic specialists as unsuitable for the use of opioid-poor anesthesia combined with epidural block analgesia. ?History of chronic pain, long-term alcohol consumption, and drug abuse. ?Pregnant women ? Patients who refuse to use analgesic pumps ? Patients who are allergic to test drugs ? Patients who are unable to cooperate or communicate with each other.

Design outcomes

Primary

Measure	Time frame
QoR-15;	—

Secondary

Measure	Time frame
NRS score;total opioid use;The time of the outbreak of pain;First time out of bed activity;	—

Countries

china

Contacts

Public Contactchao liang

Zhongshan Hospital (Xiamen), Fudan University

liang.chao@zs-hospital.sh.cn+86 159 2167 9955

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026