major depressive disorder
Conditions
Interventions
low-frequency fixed stimulation group:10Hz transcranial alternating current stimulation once daily
high-frequency fixed stimulation group:10Hz transcranial alternating current stimulation twice daily
low-frequency individualized stimulation group:individual alpha frquency transcranial alternating current stimulation once daily
high-frequency individualized stimulation group:individual alpha frequency transcranial alternating current stimulation twice daily
Sponsors
Beijing Anding Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 55 Years
Inclusion criteria
Inclusion criteria: 1: Meeting DSM-V diagnostic criteria for major depressive disorder without psychotic symptoms 2: Age 18-55 3: No treatment with MECT/ECT, TMS, tDCS 1 month prior to enrollment 4: No psychiatric medication use 14 days prior to enrollment 5: 17-item Hamilton Depression Rating Scale (HAMD-17) score =17 at enrollment and HAMD-17 entry 1 (depressed mood) score =2 6: Have understood all aspects of the study and signed the informed consent form
Exclusion criteria
Exclusion criteria: 1: Meets DSM-V Other Psychiatric Diagnoses 2: Serious or unstable organic disease 3: Pregnant and breastfeeding women, patients unable to use suitable contraception during the trial period 4: History of seizures, epilepsy, hydrocephalus or CNS tumors, acute brain injury and infection 5: Impaired skin integrity at the electrode placement site, allergy to electrode gels or adhesives 6: With implantable electronic stimulator 7: Previous manic or hypomanic episodes 8: with a HAMD-17 3 (suicide) score of =3 9: Patients with prior suicidal behavior or existing strong suicidal ideation 10: Participants in any other clinical trial within 1 month prior to baseline 11: The researcher believes that there are circumstances that make participation in this study inappropriate 12: Researchers directly participating in this study or their immediate family members
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| effectiveness at the end of treatment; | — |
Secondary
| Measure | Time frame |
|---|---|
| Early effectiveness at 1 week;HAMD-17 factor scores;Effectiveness at 4 week;Changes in QIDS-SR16;Changes in GAD-7;Changes in HAMA;electroencephalography;Perceived Deficit Questionnaire for Depression 5-item,PDQ-5D;Sheehan Disability Scale, SDS;Ask Suicide-Screening Questions, ASQ; | — |
Countries
China
Contacts
Public ContactJingjing Zhou
Beijing Anding Hospital
Outcome results
None listed