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Study on changes in oral microbiota in liver cancer patients and the acceleration of malignant progression of rat hepatocellular carcinoma by periodontitis

Study on changes in oral microbiota in liver cancer patients and the acceleration of malignant progression of rat hepatocellular carcinoma by periodontitis

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2400082256
Enrollment
Unknown
Registered
2024-03-25
Start date
2024-03-25
Completion date
Unknown
Last updated
2024-04-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

liver cancer

Interventions

Liver disease group:Supragingival scaling
control group:None

Sponsors

The First Affiliated Hospital of Xi'an Jiaotong University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Liver disease group: 1) Age = 18 years old, regardless of gender; 2) Having a good mental state; 3) Confirmed as liver cancer or cirrhosis. Control group: 1) Age = 18 years old, regardless of gender; 2) Having a good mental state; 3) Not suffering from liver disease.

Exclusion criteria

Exclusion criteria: 1) Suffering from primary or secondary tumors in other areas; 2) Suffering from other serious systemic diseases; 3) Existence of consciousness disorders; 4) Used antibiotics for treatment within 3 months.

Design outcomes

Primary

MeasureTime frame
Aspartate aminotransferase;Alanine aminotransferase;total bilirubin;Direct Bilirubin;cholinesterase;Prothrombin time;Activated partial thromboplastin time;Fibrinogen;Thrombin time;D-dimer;Number of teeth in the oral cavity;calculus index;Gingival bleeding index;Plaque index;probing depth ;decayed, missing and filled (permanent) teeth;Oral microbial diversity;fecal microbial diversity ;Differences in species composition of oral microbiota;Differences in species composition of fecal microorganisms;Relative abundance of oral microbial species;Relative abundance of fecal microbial species;

Secondary

MeasureTime frame
height;weight;Blood glucose;

Countries

China

Contacts

Public ContactChen Xi

The First Affiliated Hospital of Xi'an Jiaotong University

13038598996@163.com+86 189 9123 2476

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Mar 7, 2026