Acute intraoperative blood loss
Conditions
Interventions
Control group:From anesthesia induction to postoperative recovery of the subjects, continuous infusion of 8ml/(kg · h) sodium lactate Ringer solution was used as the basic infusion volume. During this
Experimental group:From anesthesia induction to the start of the main blood loss step during surgery, the subject was treated with succinylated gelatin blood diluent at a rate of 42ml/(kg · h) until t
Sponsors
General Hospital of the Northern Theater Command of the Chinese People's Liberation Army
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1) Intended to undergo posterior spinal surgery under general anesthesia with an expected blood loss of over 800ml; (2) 18 years old or older and 65 years old or younger; (3) American Society of Anesthesiologists Health Status Classification I-III; (4) Body mass index greater than or equal to 18kg/m2 and less than or equal to 30kg/m2; (5) Able to understand the steps and protocol of this study, willing to sign an informed consent form, and able to strictly follow the protocol to complete the study.
Exclusion criteria
Exclusion criteria: (1) Emergency surgery or cancellation of surgery for various reasons; (2) Combined anterior posterior spinal surgery; (3) Having contraindications to general anesthesia or a history of anesthesia accidents; (4) Allergy to drugs or products that may be involved in this study, such as succinylated gelatin and propofol, or compliance with corresponding contraindications; (5) Preoperative severe cardiovascular disease, including but not limited to uncontrolled hypertension (systolic blood pressure greater than or equal to 180mmHg and/or diastolic blood pressure greater than or equal to 110mmHg), aneurysm, severe arrhythmia, heart failure, and a history of myocardial infarction within 6 months; (6) Preoperative concomitant liver and kidney dysfunction; (7) Preoperative concomitant coagulation dysfunction; (8) Before surgery or immediately after anesthesia induction, the hemoglobin concentration is below 100g/L or the hematocrit is below 30%; (9) Postoperative verification showed that the blood loss did not reach 800ml; (10) The researcher determined that there were any other factors that were not suitable for inclusion in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The decrease in postoperative hemoglobin concentration compared to preoperative levels in a conscious state;Postoperative acute kidney injury; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative decrease in hematocrit compared to preoperative levels in a conscious state;Postoperative platelet count decreases compared to preoperative levels in a conscious state;Intraoperative infusion of suspended red blood cells and plasma volume;Intraoperative arterial blood pressure fluctuations;Intraoperative prothrombin time;Intraoperative activation of partial thromboplastin time;Intraoperative fibrinogen concentration;Intraoperative thrombin time;Intraoperative D-dimer concentration;Intraoperative thromboelastography (regular detection) parameters;Perioperative myocardial injury;Differences in serum amino terminal brain natriuretic peptide precursor concentrations after surgery; | — |
Countries
China
Contacts
Public ContactYugang Diao
General Hospital of the Northern Theater Command of the Chinese People's Liberation Army
Outcome results
None listed