Basilar Artery Occlusion
Conditions
Interventions
Endovascular thrombectomy combined with drug treatment group:None
Sponsors
The First Affiliated Hospital of University of Science and Technology of China
Eligibility
Sex/Gender
All
Age
18 Years to 120 Years
Inclusion criteria
Inclusion criteria: 1) Symptoms and signs compatible with ischemia in the basilar artery territory; 2) Basilar artery occlusion confirmed by computed tomographic angiography (CTA)/ magnetic resonance angiography (MRA)/ digital substraction angiography (DSA); 3) Age of 18 years or older; 4) Time from stroke onset to randomization within 12 hours of estimated time of basilar artery occlusion; 5) The patient or their legal representative signs an informed consent form; 6) National Institutes of Health Stroke Scale (NIHSS) score =10 at the time of neuroimaging.
Exclusion criteria
Exclusion criteria: 1) Premorbid mRS =3 for patients185 mmHg or diastolic pressure >110 mmHg, and cannot be controlled by antihypertensive drugs; 7) Known genetic or acquired bleeding diathesis, lack of anticoagulant factors, or oral anticoagulant drugs and INR > 1.7; 8) Blood glucose 22.2 mmol / L; platelet count < 50×10^9 / L, or hematocrit < 25%; 9) Life expectancy < 1 year; 10) Patients that cannot complete 90-day follow-up (e.g. no fixed residence, overseas patients, etc.); 11) The patient develops acute ischemic cerebral infarction within 48 hours after percutaneous coronary or cerebrovascular intervention surgery or major surgery (if it exceeds 48 hours, the patient can be enrolled); 12) Premorbid cerebrovascular inflammation; 13) Premorbid nervous system disease or mental disorders hindering the assessment of 3-month functional outcomes. Imaging exclusion criteria 14) CT/MR shows intracranial hemorrhage (patients with microbleeds on MR can be included if lesion diameter =5mm); 15) CTA/MRA/DSA shows the vascular anatomy is severely tortuous, has an anatomic variation, or is severely stenotic or dissected that would preclude the navigation of the thrombectomy devices to the target vessel; 16) PC-ASPECTS on CT/CTA-Source Images/MRI-DWI <6 for patients <80 years (<8 for patients =80 years); 17) CT or MR shows the cerebellar infarction with obvious space occupying effect and obvious compression of the fourth ventricle; 18) Complete bilateral thalami or bilateral brainstem infarction confirmed by CT/MR; 19) Simultaneous occlusion of both anterior and posterior circulation confirmed by CTA/MRA/DSA; 20) Intracranial tumors (except small meningiomas).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| modified Rankin scale ; | — |
Secondary
| Measure | Time frame |
|---|---|
| EQ-5D-5L Score;Barthel index;All-Cause Mortality; | — |
Countries
China
Contacts
Public ContactWei Hu
The First Affiliated Hospital of University of Science and Technology of China
Outcome results
None listed