SLE
Conditions
Interventions
Sponsors
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: 1) Inclusion criteria for SLE patients ? Age 18-50 years old, education years =5 years; ? No MRI contraindications; (3) Meet the latest 2019 EULAR/ACR SLE classification standard and 1999 ACR NPSLE classification standard; (4) SLE patients with initial treatment and disease course within 15 months were preferentially included. 2) Inclusion criteria for healthy controls ? Age 18-50 years old, education years =5 years; ? No major physical diseases (such as acute cerebrovascular events, neurodegenerative diseases, craniocerebral injury, craniocerebral surgery, schizophrenia, claustrophobia, malignant tumors, etc.) were evaluated by doctors; ? Age, sexwere matched with SLE group
Exclusion criteria
Exclusion criteria: ? Patients clearly have severe cervical spondylosis, mental illness, malignant tumor brain metastases and other neuropsychiatric manifestations may appear similar to NPSLE, but it is difficult to identify them. ? Previous neurological diseases such as stroke, epilepsy, intracranial infection, and space occupation; ? This MRI revealed fresh cerebral hemorrhage and massive cerebral infarction; Magnetic resonance scanning contraindications (such as metal implants in the body, including metal dentures, pacemakers, coronary stents, steel nails, steel plates, etc.); , ? Can not cooperate with MRI examination and neuropsychological scale test.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MRI brain oxygen metabolism parameters; | — |
Secondary
| Measure | Time frame |
|---|---|
| MoCA score;BILAG score;SLEDAI-2000 score;HADS score; | — |
Countries
China
Contacts
Public ContactDong Lingli
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Outcome results
None listed