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Effect of esketamine on postoperative depression and Homer1a protein expression in breast cancer patients

Effect of esketamine on postoperative depression and Homer1a protein expression in breast cancer patients - ASLATDRXAHZSHYYJHDBBDLDYX

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2400082215
Enrollment
Unknown
Registered
2024-03-23
Start date
2024-03-24
Completion date
Unknown
Last updated
2024-03-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

breast cancer

Interventions

Experimental group:ketamine
Control group:Saline

Sponsors

Department of Anesthesiology, General Hospital of the Western Theater of the Chinese People's Liberation Army
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: ASA Grading I.-III; Age 18-65 years; Patients requiring modified radical resection of breast cancer under general anesthesia; No history of drug allergies; Signed informed consent;

Exclusion criteria

Exclusion criteria: Patients with a history of severe cardiac, cerebrovascular, respiratory, hepatic, or renal disease; Patients with severe, poorly controlled hypertension; Those who are unable to communicate (coma, deep dementia or language disorder); Patients with hyperthyroidism; history of alcohol or opioid abuse; People with severe anxiety and depression; Patients who have been taking sedative, anticonvulsant and other drugs for a long time;

Design outcomes

Primary

MeasureTime frame
HADS Scales;Homer1a protein;

Secondary

MeasureTime frame
IL-4;IL-10;VAS scale;

Countries

China

Contacts

Public Contactgonggu

General Hospital of the Western Theater of the Chinese People's Liberation Army

2560806317@qq.com+86 173 6013 7572

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026