Attention Deficit Hyperactivity Disorder
Conditions
Interventions
Methylphenidate-treated group:Methylphenidate treatment
Atomoxetine-treated group:Atomoxetine treatment
Sponsors
Peking University Sixth Hospital
Eligibility
Sex/Gender
All
Age
6 Years to 17 Years
Inclusion criteria
Inclusion criteria: (1) Children's outpatient clinic of the Sixth Hospital of Peking University, consultation, meeting the diagnostic criteria of ADHD in DSM-IV, preliminary clinical diagnosis by child psychiatrist/child health practitioner with the title of attending physician or above through non-stereotypical clinical interviews with parents and children, and then verified by semi-stereotypical diagnostic tool, K-SADS-PL-DSM5 (Kiddie-Schedule for Affective Disorders and Schizophrenia for School-Aged Children Present and Lifetime Version, Kiddie-Schedule for Affective Disorders and Schizophrenia for School-Aged Children Questionnaire Present and Lifetime Version) was verified; (2) absence of co-morbidities; (3) age 6-17; (4) IQ = 80; and (3) age 6-17 years; (4) IQ =80; (5) no prior medication for ADHD; (6) right-handedness (only children participating in the magnetic resonance scan); and (7) informed consent from the subject and his/her guardian.
Exclusion criteria
Exclusion criteria: (1) schizophrenia, mental retardation or pervasive developmental disorder, autism (clinician-diagnosed autism or Social Responsiveness Scale score =60), and tic disorders; (2) affective disorders, anxiety disorders, and oppositional defiant disorder/Character disorder (ODD/CD); (3) narrow-angle glaucoma; (4) dysphagia or severe gastrointestinal stenosis; (5) co-administration of other psychotropic medications or use of non-pharmacological treatments for ADHD in the last 30 days or since the start of the study; (6) hypertension, cardiac dysfunction, or rapid cardiac arrhythmias suitable for trial drug treatment; and (5) Persons who have co-administered other psychotropic medications or applied non-pharmacological treatments for ADHD within the last 30 days or since the start of the study; (6) Persons with cardiovascular diseases such as hypertension, cardiac insufficiency, tachyarrhythmias, etc., which are not suitable for treatment with the experimental medication; (7) For children participating in the magnetic resonance imaging scanning, it is necessary to rule out the existence of conditions that are not suitable for the MRI, such as the presence of metallic implants in the body (including non-removable dentures) or the presence of claustrophobia. or claustrophobia.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cognitive behavioral data; | — |
Secondary
| Measure | Time frame |
|---|---|
| MRI data;EEG data; | — |
Countries
China
Contacts
Public ContactLi Sun
Peking University Sixth Hospital
Outcome results
None listed