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A real-world study on the efficacy and safety of multicenter, prospective, open, and naturally selected levosimendan in the treatment of acute heart failure or acute exacerbation of chronic heart failure

A real-world study on the efficacy and safety of multicenter, prospective, open, and naturally selected levosimendan in the treatment of acute heart failure or acute exacerbation of chronic heart failure

Status
Recruiting
Phases
Phase 4
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2400082198
Enrollment
Unknown
Registered
2024-03-22
Start date
2024-03-23
Completion date
Unknown
Last updated
2024-03-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute heart failure or acute exacerbation of chronic heart failure

Interventions

Experimental group:Intravenous infusion of levosimendan

Sponsors

Shandong University of Traditional Chinese Medicine Affiliated Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 100 Years

Inclusion criteria

Inclusion criteria: Selection criteria (those who meet all of the following criteria can be selected for this clinical study) (1) Meets the diagnostic criteria for acute heart failure in the ESC Guidelines for the Diagnosis and Treatment of Acute and Chronic Heart Failure: dyspnea/wheezing and/or NT proBNP or BNP elevation (the diagnostic threshold for AHF is BNP>400 pg/mL; NT proBNP should refer to age factors, below 50 years>450 pg/mL, 50-75 years>900 pg/mL, and above 75 years>1800 pg/mL); (2) Age = 18 years old, regardless of gender; (3) Those who have signed the informed consent form.

Exclusion criteria

Exclusion criteria: Exclusion criteria (those who fall under one of the following circumstances cannot be included in this clinical study) (1) Patients with non cardiogenic asthma caused by other reasons; (2) Patients with comorbidities related to mental disorders, which affect the description of symptoms; (3) The researchers believe that it is not suitable for patients to participate in this study.

Design outcomes

Secondary

MeasureTime frame
Changes in heart failure grading after treatment (NYHA);;Patient satisfaction with the improvement time and efficacy of heart failure symptoms after treatment/Scale (Likert).;

Primary

MeasureTime frame
Changes in NT proBNP or BNP levels and relief time of wheezing symptoms in patients with acute or chronic heart failure before and after treatment;

Countries

China

Contacts

Public ContactFan Kailiang

Shandong University of Traditional Chinese Medicine Affiliated Hospital

15098966658@126.com+86 150 9896 6658

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026