Ischemic stroke
Conditions
Interventions
Real Stimulation group:1.All patients receive fundamental neurological care, including clinical pharmacotherapy, standard nursing care, and basic rehabilitation therapy.
2.The earplug of the transcuta
Sham Stimulation group:1.All patients receive fundamental neurological care, including clinical pharmacotherapy, standard nursing care, and basic rehabilitation therapy.
2.The earplug of the transcuta
Sponsors
Nanjing Drum Tower Hospital Group Suqian Hospital
Eligibility
Sex/Gender
All
Age
30 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) Patients with first-onset ischemic stroke confirmed by CT or MRI; (2) Onset of stroke within acute phase, with a duration ranging from 0.5 hours to 14 days; (3) Age between 30 and 75 years old; (4) Hemiplegia; (5) Stable vital signs, conscious, able to actively cooperate with assessment and treatment, and have good compliance; (6) Support from the patient's family and signed informed consent form.
Exclusion criteria
Exclusion criteria: (1) Concomitant peripheral nerve injury, Parkinson's disease, multiple sclerosis, and other neurological disorders; (2) Severe cognitive, speech, or mental disorders; (3) Presence of medical devices such as cardiac pacemakers or cochlear implants; (4) History of ear infection or loss, surgical history involving the vagus nerve, or vagus nerve damage; (5) Progressive decline in cardiac, pulmonary, hepatic, or renal function; (6) Bradycardia (heart rate < 60 bpm).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fugl-Meyer rating scale for upper extremity (FMA-UE); | — |
Secondary
| Measure | Time frame |
|---|---|
| Brunnstrom Stages (Upper Limb and Hand); Modified Barthel Index. (MBI);Cytokine Levels: Measurement of Serum BDNF and NGF Levels; National Institutes of Health Stroke Scale (NIHSS);Safety Assessment: Monitoring of heart rate, blood pressure, electrocardiogram, and recording adverse reactions.; | — |
Countries
China
Contacts
Public ContactBaoshan Xu
Nanjing Drum Tower Hospital Group Suqian Hospital
Outcome results
None listed