Total knee arthroplasty
Conditions
Interventions
Fondaparinux (FPX) group:Fondaparinux Sodium Injection
LMWH group:Enoxaparin Sodium Injection
Sponsors
The Affiliated Hospital of Panzhihua University
Eligibility
Sex/Gender
All
Age
50 Years to 76 Years
Inclusion criteria
Inclusion criteria: (1) All patients were negative for lower extremity DVT by ultrasound examination before the trial; (2) The operation indication of knee joint replacement was clear, and the unilateral TKA was done with the first time; (3) The previous coagulation function was normal and there was no hematological disease; (4) All patients with no previous vascular embolic disease; (5) All patients with no history of anticoagulant use; (6) All patients with normal result in other laboratory tests; (7) No other procoagulant or anticoagulant drugs were used one week before surgery.
Exclusion criteria
Exclusion criteria: (1) The patients with other severe organic diseases; (2) The patients with blood transfusion history, severe bleeding tendency, local or systemic infection that could not be controlled in the near future; (3) The patients with invasive operation of knee joint in the past three months; (4) The patients with other contraindications who were not suitable for operation; (5) The patients with mental illness; (6) The patients who were allergic to the test drug; (7) Preoperative parasis of both lower extremities found to have signs of DVT.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Coagulation function indicators;Thromboelastography indicators; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hemorheological indicators;Lower limb blood flow velocity;DVT incidence rate;Adverse reactions; | — |
Countries
China
Contacts
Public ContactYang Yong
The Affiliated Hospital of Panzhihua University
Outcome results
None listed