Postoperative delirium
Conditions
Interventions
The remazolam group(R1 group):Remazolam was given 0.15mg/kg for general anesthesia induction
The remazolam group(R2 group):Remazolam was given 0.3mg/kg for general anesthesia induction
Propofol group (P group):General anesthesia was induced with propofol 1.5mg/kg
Sponsors
The General Hospital of the PLA Northern Theater Command
Eligibility
Sex/Gender
All
Age
60 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Age 60-80 years old, gender unlimited; 2. Patients with tracheal intubation and general anesthesia under non-cardiac surgery; The operation site should be abdominal operation. Duration of operation 4h; 3. ASA scores ? ~ ?; 4. BMI 18-30kg/m2; 5. Voluntarily sign informed consent.
Exclusion criteria
Exclusion criteria: 1. Unable to communicate verbally due to deafness; 2. Patients with difficult airway were improved Mallampati grade ?; 3. Preoperative delirium or dementia; 4. History of severe cardiovascular disease and uncontrollable diabetes before surgery; Serious injury or disease of vital organs such as the lungs, brain, liver or kidney; 5. Patients with severe consciousness disorder or mental system disease (schizophrenia, mania, insanity, etc.) and cognitive dysfunction; 6. Intolerance or allergy to benzodiazepines; 7. History of alcoholism; And a history of drug addiction or other substance abuse.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative delirium; | — |
Secondary
| Measure | Time frame |
|---|---|
| Onset and duration of delirium;Quality of awakening;The time of onset of sedation until loss of consciousness;Induction success rate of general anesthesia;Cumulative doses of vasoactive drugs;Total amount of remazolam, remifentanil and propofol used during operation;Blood pressure, heart rate, BIS ;Correlation between Remazolam and BIS;Pain measurement;Incidence of postoperative nausea and vomiting;Incidence of adverse reactions (hypotension, bradycardia, injection pain);Postoperative recovery quality; | — |
Countries
China
Contacts
Public ContactDiao Yugang
The General Hospital of the PLA Northern Theater Command
Outcome results
None listed