None
Conditions
Interventions
Remimazolam group:Anesthesia induction: A constant infusion rate of remimazolam1 mg/kg/h in Group R until consciousness was disappeared. During maintenance of anesthesia, the remimazolam group was mai
Midazolam group:Anesthesia induction: midazolam 0.1 mg/kg intravenously 20-30 seconds in Group M. Anesthesia maintenance: If the total time exceeds 150 minutes starting from induction of anesthesia to
Sponsors
The Second Affiliated Hospital of Xi'an Medical University
Eligibility
Sex/Gender
All
Age
65 Years to 88 Years
Inclusion criteria
Inclusion criteria: Elderly patients = 65 years old who underwent elective surgery under general anesthesia, regardless of gender; ASA grade I - III; Body mass index = 30kg / m2; The patient or authorized family member voluntarily signed and dated the informed consent, which was approved by the institutional review committee before the patient participated in the study; Patients were willing and able to comply with the study requirements and were able to follow up on the 7th day after operation.
Exclusion criteria
Exclusion criteria: Patients known to be allergic to benzodiazepines, flumazenil, opioids and naloxone, or patients with diseases that prohibit these drugs; Patients with a history of cerebral infarction; Patients treated with benzodiazepines for a long time (such as insomnia, anxiety and spasm); Patients treated with opioids for a long time; Patients with positive drug abuse screening or positive serum ethanol; Patients with a history of drug or alcohol abuse in the past 2 years; Patients who received any investigational drug within 30 days before admission or less than 7 half lives, whichever is longer; Patients who have participated in the clinical trial of remimazolam; Patients who are unable to communicate well with the investigator or who are considered unsuitable by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Loss of consciousness time; | — |
Secondary
| Measure | Time frame |
|---|---|
| PACU stay time;Extubation time; | — |
Countries
China
Contacts
Public ContactYang Wanjun
The Second Affiliated Hospital of Xi'an Medical University
Outcome results
None listed