Depressive, Anxiety, and Somatic Symptom Disorders
Conditions
Interventions
Observation control group:No TMS intervention
Sponsors
The First Affiliated Hospital of China Medical University
Eligibility
Sex/Gender
All
Age
13 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Right-handed, males and females aged between 13 and 60 years. 2. Have not used psychiatric medications before. 3. Healthy control group without a history of DSM-5 diagnosed illnesses. 4. Patients meet the diagnostic criteria for Major Depressive Disorder, Generalized Anxiety Disorder, or Somatic Symptom Disorder according to DSM-5, have no family history of cyclothymic or bipolar disorders, and are experiencing their first episode. 5. Willing to participate and consent to adhere to the study protocol, and undergo all relevant examinations. If under 18 years of age, parental consent is required.
Exclusion criteria
Exclusion criteria: 1. Coexisting other mental disorders (such as schizophrenia, substance dependence, autism, intellectual disability, etc.). 2. History of head injury, loss of consciousness, cranial surgery, central nervous system diseases (such as epilepsy, encephalitis, stroke, hemorrhage, etc.), cardiovascular diseases (such as hypertension, coronary heart disease, heart failure, arrhythmia, etc.), other severe internal diseases (such as diabetes, renal or hepatic insufficiency, thyroid dysfunction, respiratory diseases, etc.). 3. Patients with alcohol or other sedative addictive drug abuse or dependence, such as morphine. 4. Taking beta-blockers. 5. Contraindications to magnetic resonance imaging (MRI) scans and dTMS treatment, such as having a pacemaker, metal implants, metal dentures, cochlear implants, etc. 6. Women of childbearing age who cannot rule out pregnancy. 7. Excessive head movement (>3mm, >3°) during functional magnetic resonance imaging (fMRI) scans. 8. Abnormal intracranial structures found on magnetic resonance imaging, such as space-occupying lesions.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hamilton Depression Rating Scale (HAMD);Hamilton Anxiety Rating Scale (HAMA);Flow-mediated vasodilatation (FMD); Morphological parameters and mean capillary density ;Breathing-induced cerebral oxygenation reserve (B-CORE) ;Breathing-induced myocardial oxygenation reserve (B-MORE) B-MORE;Heart rate variability (HRV); | — |
Secondary
| Measure | Time frame |
|---|---|
| Patient Health Questionnaire Somatic Symptom Scale (PHQ-15);Amplitude of low-frequency fluctuation (ALFF); | — |
Countries
China
Contacts
Public ContactTing Liu
the First Affiliated Hospital of China Medical University
Outcome results
None listed