Sleep and sleep disorders
Conditions
Interventions
Esketamine-dexmedetomidine combination group(Group ED):Esketamine-dexmedetomidine
Esketamine group(Group E):Esketamine
Dexmedetomidine group(Group D):Dexmedetomidine
Sponsors
Northern Jiangsu People's Hospital
Eligibility
Sex/Gender
All
Age
65 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1: It is planned to undergo radical surgery for gastrointestinal tumor under general anesthesia 2: Age =65 years old 3: ASA grade I-III 4: Informed consent, voluntary participation in the trial, and signed by the patient informed consent
Exclusion criteria
Exclusion criteria: 1.Sick sinus syndrome, severe bradycardia (heart rate < 50 beats/min), or degree II or above atrioventricular block without pacemaker; 2. Allergic to dexmedetomidine or esketamine; 3: Congenital heart disease or other serious cardiovascular disease above NYHA level III 4: Obstructive sleep apnea syndrome or STOP-Banq score was 3 5: Hyperthyroidism or pheochromocytoma 6: History of schizophrenia, epileptic carbuncle and myasthenia gravis 7: Preoperative delirium or communication disorder 8: Severe liver dysfunction (ChildePugh Grade C) 9: Severe renal dysfunction (preoperative dialysis) 10: Patients weighing <40kg or otherwise deemed unfit to participate in the study 11: Preoperative Pittsburgh Sleep Quality Index (PSQI) higher than7 12: Inability to use a patient-controlled IV analgesia pump 13: Do not agree to participate in this study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative sleep disturbance; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative anxiety and depression scores;Postoperative pain evaluation;Smart bracelet monitoring;Postoperative quality of recovery score, QoR-40;Montreal Cognitive Assessment, MoCA;Confusion Assessment Method, CAM; | — |
Countries
China
Contacts
Public ContactJuGao
Northern Jiangsu People's Hospital
Outcome results
None listed