Hypertension in the elderly
Conditions
Interventions
R:Patients in remimazolam group were given 6mg/kg/h, with a total dose of 0.3mg/kg of remimazolam
P: The propofol group was given 2mg/kg propofol
Sponsors
The First Affiliated Hospital of University of Science and Technology of China (Anhui Provincial Hospital)
Eligibility
Sex/Gender
All
Age
65 Years to 85 Years
Inclusion criteria
Inclusion criteria: (1) aged 65-80 years; (2) ASA grade II-III; (3) hypertensive patients undergoing elective surgery under general anesthesia, with expected operation time =2 hours.
Exclusion criteria
Exclusion criteria: 1) BMI 35 kg/m2; (2) Systolic blood pressure =180 and/or diastolic blood pressure =110mmHg on the first day before surgery; (3) patients undergoing cardiac surgery or emergency surgery; (4) allergy to or contraindication to benzodiazepines, opioids, propofol or their components; (5) Cardiac function grade 3 or above, severe arrhythmia requiring cardiology treatment, acute heart failure, acute myocardial infarction within the past three months; Severe COPD or severe interstitial lung disease, respiratory failure; Liver and kidney dysfunction was defined as chronic liver damage, AST and/or ALT=2.5×ULN, TBIL=1.5×ULN; "Chronic renal failure without dialysis, urea or urea nitrogen =1.5×ULN, or serum creatinine =2 mg/dl;" (6) having a history of epilepsy or other mental disorders or taking psychotropic drugs, or a history of cognitive impairment; (7) Unplanned ICU admission; (8) participated in other research within three months; (9) The patient refused to sign the informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The changes of MAP (including the maximum ? value of mean arterial pressure) at each time point (T0-T5) in the two groups were compared; | — |
Secondary
| Measure | Time frame |
|---|---|
| The changes of heart rate (including the maximum ? value of heart rate) at each time point (T0-T5) were compared between the two groups;Dosage of vasoactive agents;Lactic acid value;Blood glucose values; | — |
Countries
China
Contacts
Public ContactSheng Wang
The First Affiliated Hospital of University of Science and Technology of China (Anhui Provincial Hospital)
Outcome results
None listed