Pleural diseases
Conditions
Interventions
Index test:Macrogene sequencing of pathogenic microorganism
Sponsors
West China Hospital of Sichuan University
Eligibility
Sex/Gender
Male
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Selection criteria for patients in the experimental group (meeting 1-3 or 1+4 ) 1) Community onset, imaging confirmed pleural effusion, and pleural effusion samples can be obtained within 4 weeks of onset; 2) Clinical symptoms of infectious pleural effusion: fever = 37.5 ?, with or without chest pain, difficulty breathing; 3) Laboratory examination (= 1 item): Elevated blood count (WBC>10.0) × 109/L or N% = 80%), PCT (>0.5ug/L), elevated CRP (>20mg/L); 4) Chest fluid examination (= 1 item): purulent, white blood cell>1000 × 106. Chest fluid pH<7.2, glucose<2.2mmol/L, G staining positive, culture positive;
Exclusion criteria
Exclusion criteria: 1) The nature of pleural effusion is leakage; 2) Clinical diagnosis of malignant pleural effusion; 3) Patients who cannot tolerate thoracocentesis or fiberoptic bronchoscopy examination; 4) Subjects who do not accept clinical research; 5) Poor compliance, unable to complete treatment and follow-up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Accuracy ;Sensitivity;Specificity; | — |
Secondary
| Measure | Time frame |
|---|---|
| Positive predicative value;negative predictive value;Pathogenic distribution; | — |
Countries
China
Contacts
Public ContactPanwen Tian
West China Hospital of Sichuan University
Outcome results
None listed