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Epigenetic modification regulates immunity endotypes of chronic rhinosinusitis with nasal polyps

Epigenetic modification regulates immunity endotypes of chronic rhinosinusitis with nasal polyps

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2400082123
Enrollment
Unknown
Registered
2024-03-21
Start date
2021-01-01
Completion date
Unknown
Last updated
2024-03-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

chronic rhinosinusitis

Interventions

NA:NA

Sponsors

the first affiliated hospital of Sun Yat-sen University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: This was a retrospective study involving patients with CRSwNP hospitalized in the First Affiliated Hospital of Sun Yat-sen University (FAH-SYSU) and Ghent University from January 2018 to December 2020.The CRSwNP was diagnosed according to European Position Paper on Rhinosinusitis and Nasal Polyps 2020 (EPOS2020)7. Nasal polyp (NP) tissues from 70 patients at FAH were collected during surgery. None of the subjects had taken oral corticosteroids, immunomodulatory drugs within 4 weeks, nasal corticosteroids or oral antibiotics within 2 weeks before surgery.

Exclusion criteria

Exclusion criteria: Patients with fungal sinusitis, antrochoanal polyp, gastroesophageal reflux disease, immunodeficiency disease, primary ciliary immobility syndrome, cystic fibrosis, and parasitic diseases were excluded from the study.

Design outcomes

Primary

MeasureTime frame
ROC curve;

Secondary

MeasureTime frame
Odds ratio;

Countries

CHINA

Contacts

Public ContactWen Weiping

the first affiliated hospital of Sun Yat-sen University

wenwp@mail.sysu.edu.cn+86 134 8020 0660

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 5, 2026