irritable bowel syndrome
Conditions
Interventions
treatment grouop:oral administration of rifaximin
control group:None (samples from subjects before treatment)
Sponsors
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Individuals who meet all the following criteria can be included in this study 1) Diagnosed with IBS-D according to the Rome IV criteria, with a degree of abdominal pain = 3 (moderate or severe symptoms interfering with normal activity); 2) Aged between the 18 and 65 years old, regardless of gender; 3) Suitable for the treatment; 4) Voluntary acceptance of the treatment and signing an informed consent form in accordance with the relevant provisions of GCP.
Exclusion criteria
Exclusion criteria: Individuals with any of the following cannot be included in this study 1) With general or specific contraindications to the provided medication; 2) Combined with cardiovascular, cerebrovascular, hepatic, renal, hematopoietic system, hyperthyroidism, diabetes mellitus, inflammatory bowel disease and other serious primary diseases diseases, or serious diseases affecting their survival (such as tumors, etc.) and psychiatric patients. 3) Women who are pregnant, breastfeeding, or planning to be pregnant. 4) Are suspected or have a history of alcohol or drug abuse. 5) Cognitive impairment that prevents full informed consent. 6) Patients who have received medication for IBS within the last 2 weeks and who have participated in other clinical trials within the last month. 7) Patients with conditions unsuitable for inclusion in the study assessed by the researchers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| fecal metagenome;fecal metabolome; | — |
Secondary
| Measure | Time frame |
|---|---|
| Irritable Bowel Syndrome-Symptom Severity Scale;Irritable Bowel Syndrome-Quality of Life; | — |
Countries
China
Contacts
Public ContactXiaohua Hou
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Outcome results
None listed