Malignant Pleural Effusions
Conditions
Interventions
control group:First 24-hour drainage of 1000ml
treatment group:First 24-hour drainage of 1500ml
treatment group:First 24-hour drainage of 2000ml
treatment group:First 24-hour drainage of 2500ml
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Patients with MPE with symptoms of dyspnoea who are considered by the investigators to have an indication for fluid drainage via IPC; 2. Imaging such as ultrasound or CT suggests that the volume of pleural effusion is =3000ml; 3. Predicted survival ?6 months.
Exclusion criteria
Exclusion criteria: 1. Patients = 18 years of age; 2. Chest wall disease that may prevent effective drainage via closed chest drainage (IPC); pleural infection; celiac disease; pregnancy or breastfeeding; 3. Uncorrectable bleeding tendency; 4. Those who are unable to obtain informed consent or comply with the trial protocol.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Vital signs, laboratory tests, and any other adverse events, including type, incidence, severity, time, etc,with severity assessed with reference to CTCAE (version 5.0); | — |
Secondary
| Measure | Time frame |
|---|---|
| Dyspnoea relief rate;Cough relief rate;Accelerated heart rate mitigation rate; | — |
Countries
China
Contacts
Public ContactYongsheng Wang
West China Hospital of Sichuan University
Outcome results
None listed