infectious necrosis pancreatitis
Conditions
Interventions
Retroperitoneal approach debridement in infectious necrotizing pancreatitis:No Intervention, observational study
Sponsors
Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1) Aged between 18 and 70. 2) Acute pancreatitis was diagnosed and laparoscopic debridement through retroperitoneal approach was required. 3) Peripancreatic necrotic accumulation or enveloping necrotic puncture clearly indicates infection, imaging clearly indicates infection, or clinical manifestations consider the presence of infection. 4) ASA Level I-IV. 5) Voluntarily participate in the study and sign the informed consent. If the subject is unable to read and sign the informed consent due to incapacity or other reasons, his/her guardian shall represent the informed process and sign the informed consent. If the subject does not have the ability to read the informed consent (e.g., illiterate subjects), a witness must witness the informed process and sign the informed consent.
Exclusion criteria
Exclusion criteria: 1) Chronic pancreatitis or pancreatitis associated with pancreatic tumors. 2) Coagulation disorder can not be corrected (defined as blood coagulation disorder caused by vascular wall abnormalities, lack of coagulation factors, etc., resulting in an abnormal manifestation of bleeding, INR value is greater than 1.5 and does not continue to improve after drug treatment, plasma infusion treatment, etc.) or anticoagulation treatment. 3) Patients with serious underlying diseases (defined as diseases requiring hospitalization, such as chronic wasting diseases, endocrine disorders, severe chronic obstructive pulmonary disease, etc.), malignancies, a history of immune diseases, or long-term hormonal drug use. 4) Patients not suitable for laparocopic surgery (such as bleeding, intestinal perforation, abdominal septum syndrome, etc.). 5) Acute pancreatitis > 30 days after onset 6) Participated in other clinical trials in the past 3 months. 7) Other vulnerable groups, including those with mental illness, those with cognitive impairment, pregnant women, breastfeeding women, etc. 9) Prior surgery due to confirmed or suspected infectious necrosis 9) Other conditions deemed unsuitable for inclusion by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Severe Complication;organ failure;Inflammation index; | — |
Secondary
| Measure | Time frame |
|---|---|
| 30-day mortality;Other complications;Number of Surgery ;postoperative hospital stay; | — |
Countries
China
Contacts
Public ContactBo Shen
Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
Outcome results
None listed