Stroke
Conditions
Interventions
Dual-target stimulation group:Incorporating iTBS stimulation on the foundation of cognitive rehabilitation training, targeting the left dorsolateral prefrontal cortex and the precuneus.
Single-target stimulation group:Incorporating iTBS stimulation on the foundation of cognitive rehabilitation training, targeting the left dorsolateral prefrontal cortex
Sham stimulation group:Utilizing sham iTBS stimulation (treatment coil flipped by 90°) on the backdrop of cognitive rehabilitation training, with a target area limited to the left dorsolateral prefron
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1)Patients with a documented history of stroke, confirmed by head CT or MRI. 2)Age =18 years, native Mandarin speakers, and right-handed. 3)Cognitive impairment, as evidenced by a Montreal Cognitive Assessment (MoCA) score <26. 4)Informed consent and willing to participate in the study.
Exclusion criteria
Exclusion criteria: 1)Patients with severe cardiorespiratory diseases, multi-organ failure, malignant tumors, or severe psychiatric disorders. 2)Patients with intracranial metal implants or implanted cardiac pacemakers. 3)Patients with a history of epilepsy or a family history of epilepsy. 4)Patients who are in a comatose state, have severe cognitive impairment, severe motor impairments, complete aphasia, or sensory aphasia, and are unable to actively participate in rehabilitation training. 5)Patients with significant cognitive impairment prior to the stroke. 6)Patients who have previously undergone transcranial magnetic treatment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total score of Montreal Cognitive Assessment; | — |
Secondary
| Measure | Time frame |
|---|---|
| Total score of Mini-Mental State Examination;Total score of Modified Barthel Index;Resting-State EEG Power Spectral Density;Global Mean Field Power (GMFP);Event-Related Spectral Perturbations (ERSP);Functional near infrared spectroscopy imaging; | — |
Countries
China
Contacts
Public ContactJing He
Rehabilitation Medicine Center West China Hospital Sichuan University
Outcome results
None listed