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Diagnostic value of inflammatory mediators in urine in sepsis related encephalopathy

The role of inflammatory mediators in sepsis associated encephalopathy

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2400082067
Enrollment
Unknown
Registered
2024-03-20
Start date
2021-08-30
Completion date
Unknown
Last updated
2024-03-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sepsis associatted encephalopathy

Interventions

SAE:NA

Sponsors

Hunan Provincial People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: Adult patients who meet the diagnostic criteria for sepsis or sepsis encephalopathy and agree to join this study.

Exclusion criteria

Exclusion criteria: Not meeting diagnostic criteria; Age<18 years old; Pregnant women; Late stage tumors, etc.

Design outcomes

Primary

MeasureTime frame
APACHE II Scoring;SOFA Scoring;Diameter of optic nerve sheath;IL-6 in urine;CRP in urine;PCT in urine;The sensitivity of urine PCT in diagnosing SAE;The specificity of urine PCT in diagnosing SAE;Positive predictive value of urine PCT for diagnosing SAE;Negative predictive value of urine PCT for diagnosing SAE;Death risk coefficient;NSE in urine;Sensitivity of urinary NSE in diagnosing SAE;The specificity of urinary NSE in diagnosing SAE;Positive predictive value of urinary NSE in diagnosing SAE;Negative predictive value of urinary NSE in diagnosing SAE;Sensitivity of urinary IL-6 in diagnosing SAE;The specificity of urinary IL-6 in diagnosing SAE;Positive predictive value of urinary IL-6 in diagnosing SAE;Negative predictive value of urinary IL-6 in diagnosing SAE;

Secondary

MeasureTime frame
PCT in blood;CRP in blood;WBC in urine;Urinary bacteria;Sensitivity of blood PCT in diagnosing SAE;The specificity of blood PCT in diagnosing SAE;Positive predictive value of blood PCT in diagnosing SAE;Negative predictive value of blood PCT in diagnosing SAE;

Countries

CHINA

Contacts

Public ContactTonglin Lu

Department of Critical Care Medicine, Hunan Provincial People's Hospital

tonglinlu@163.com+86 158 7492 4663

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026