Parkinson disease
Conditions
Interventions
Acupuncture group:Acupuncture and anti-Parkinson's drugs
Waiting group:Anti-Parkinson's drugs
Sham-acupuncture group:Sham-acupuncture and anti-Parkinson's drugs
Sponsors
The First Affiliated Hospital of Guangzhou University of Chinese Medicine
Eligibility
Sex/Gender
All
Age
35 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1) Diagnosed with Idiopathic PD and constipation; 2) Hoehn-Yahr scale grades 1 to 3; 3) Good compliance, able to understand the research content, and cooperate with the completion of the defecation diary and scale, and cooperate with the completion of stool collection; 4) Drugs that could affect the gut flora are not taken within 1 month, including antibiotics and probiotics; 5) Aged from 35 to 80; 6) Participate voluntarily and sign informed consent; 7) The course of Parkinson's disease is not less than 6 months, and anti-Parkinson drugs are taken regularly for more than 3 months according to regulations; 8) Did not participate in other drugs or acupuncture clinical trials within 1 month prior to inclusion in the study.
Exclusion criteria
Exclusion criteria: 1) Organic lesions of the digestive system (such as intestinal adhesions, intestinal obstruction, tumors or malformations in the gastrointestinal tract, etc.), or history of abdominal surgery or anorectal surgery that may affect intestinal transport, or systemic diseases that affect digestive motility (such as diabetes, hyperthyroidism, etc.); Serious cardiovascular and cerebrovascular diseases, hematopoietic diseases, malignant tumors or other serious life-threatening diseases; Have a clear history of mental illness or accompanied by psychotic symptoms; 2) Skin lesions at the acupuncture site, or patients who are not suitable for acupuncture due to acupuncture, pneumothorax, spontaneous bleeding, etc., and those who are allergic or intolerant to acupuncture treatment; 3) Fear of acupuncture, pregnant and lactating women; 4) A history of substance abuse (such as alcohol, drugs, caffeine) in the past six months; 5) Use probiotics or antibiotics in the first 4 weeks; 6) Patients who developed diarrhea within the last 2 weeks were suspended from inclusion; 7) Women who have plans to have children in the near future.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Unified Parkinson's Disease Rating Scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| The Non-Motor Symptoms Scale;Stool diary;30m walking test;Gut microbiota;Lipopolysaccharide;Lipopolysaccharide-binding protein; | — |
Countries
China
Contacts
Public ContactZhuang Lixing
The First Affiliated Hospital of Guangzhou University of Chinese Medicine
Outcome results
None listed