None
Conditions
Interventions
A:Collect 3mL blood sample at 0.25 h (±5min) and 3mL milk samples at 0.25 h (± 5 min), 0.5 h (± 5 min), 1 h (±10min), 1.5 h (± 10 min), 2h (±10min) and 3h (±10min)from volunteers after articaine bucca
B:Milk was emptied before administration and at 3h after administration, and collect blood samples at 0.25 h after administration and accumulated milk between 0 and 3h after buccal mucosal infiltratio
Sponsors
Peking Union Medical College Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: All of the following criteria must be met: Fully informed and voluntarily sign an informed consent form before any specific research procedures are carried out; Lactating women without systemic disease, weight =40kg, age =18 years
Exclusion criteria
Exclusion criteria: If any of the following criteria are met, you cannot be enrolled in this study: (1) Smoking and drinking; (2) Contraindications to local anesthetics and their associated vasoconstrictors: including known or suspected allergic reactions to amide local anesthetics or sulfites; (3) History of cardiovascular disease, including unstable angina, arrhythmia, or treated or untreated hypertension, systolic blood pressure greater than 140 mm or diastolic blood pressure greater than 90 mm Hg; (4) Severe or currently symptomatic bronchial asthma;(5) soft tissue infection around any injection site; (6) Recent use of the following drugs: nonselective beta blockers, monoamine oxidase inhibitors, tricyclic antidepressants, phenothiazines, butylphenols, vasopressors, and ergot alkaloids. (7) Other factors, including but not limited to other medical history (e.g., history of mental disorders), vital signs, abnormalities, etc., that may affect the study results and interfere with their participation in the entire study, according to the investigator's judgment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Milk Drug Concentration; | — |
Secondary
| Measure | Time frame |
|---|---|
| Plasma Concentration; | — |
Countries
China
Contacts
Public ContactQuan Jing
Peking Union Medical College Hospital
Outcome results
None listed