Caries
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: Children aged 3-6 years old who have at least 16 teeth The first primary molar has fully erupted They can cooperate with oral examination and specimen collection Their parents informed consent to this study.
Exclusion criteria
Exclusion criteria: Have any genetic or systemic disease that might interfere with the results of the study Use of hormones, immune agents or any drugs that may affect the function of saliva in the last six months Used fluoride in the last six months Antibiotics in the last three months Have used probiotic drugs or products in the past week Allergic to fluoride Have orthodontic device inside the mouth
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Plaque microorganism; | — |
Secondary
| Measure | Time frame |
|---|---|
| Decayed missing filled teeth;Decayed missing filled surface;Oral hygiene index-simplified;Salivary pH;Cariostat; | — |
Countries
China
Contacts
The Affiliated Stomatological Hospital of Kunming Medical University