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Effect of continuous infusion of etomidate at different times of the day on postoperative adrenocortical function in patients under general anaesthesia

Effect of continuous infusion of etomidate at different times of the day on postoperative adrenocortical function in patients under general anaesthesia

Status
Active, not recruiting
Phases
Phase 4
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2400082034
Enrollment
Unknown
Registered
2024-03-19
Start date
2024-03-31
Completion date
Unknown
Last updated
2024-03-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

general anaesthesia

Interventions

Surgeries starting from 08:00 to 09:00 (Group E1):NA
Surgeries starting from 16:00 to 17:00 (Group E2):NA

Sponsors

The First Affiliated Hospital of Wannan Medical College
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: (1) Patients to be operated under general anaesthesia for elective lower abdominal surgery (2) Duration of surgery: 2-4h (3) Age: 18-80 years old (4) American Society of Anaesthesiologists Health Status Classification (ASA)Grade :I-III.

Exclusion criteria

Exclusion criteria: (1) Serious liver or kidney disease or infectious disease (2) Cardiovascular accident within 3 months (3) Other surgeries within 3 months (4) History of steroid treatment with endocrine disease (5) Body mass index (BMI) =30kg/m^2 or <18.5kg/m^2 (6) Preoperative blood pressure over 180/100mmHg (7) Incomplete data collection

Design outcomes

Primary

MeasureTime frame
Serum cortisol concentrations;Serum aldosterone concentrations;Serum adrenocorticotropin concentration;

Secondary

MeasureTime frame
Awakening time;Extubation time;Post-Anesthesia Care Unit stay time;QoR-15 Quality of Recovery Rating Scale Score;Length of hospitalisation;mortality rate;Types and doses of vasoactive drugs used;postoperative nausea and vomiting; Postoperative pulmonary complications;Postoperative hypertension/hypotension;Non-prophylactic antibiotic use rate;Postoperative 1st, 3rd and 6th adverse reaction follow-up records;Centre for surgery rate, blood pressure;

Countries

China

Contacts

Public ContactCHEN Yongquan

The First Affiliated Hospital of Wannan Medical College

1649661958@qq.com+86 150 0553 8061

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026