premature ovarian insufficiency ,POI
Conditions
Interventions
Control group:Artificial cycle therapy: Estradiol valerate tablets (Guangzhou Branch of Bayer Healthcare Co., Ltd. National Medicine Standard: J20080036) 1mg/ day, taken continuously for 21 days. On t
if you don't have menstrual cramps, start the next medication cycle one week after stopping taking medicine.
Experimental group:Acupoint catgut embedding in the experimental group mainly refers to the selection criteria of amenorrhea and menoxenia in Acupuncture, a textbook of the 12th Five-Year Plan of the
Sponsors
Dongzhimen Hospital Beijing University of Chinese Medicine
Eligibility
Sex/Gender
Female
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: ? Non-pregnant women of childbearing age aged 18-40; ? Sporadic menstruation or amenorrhea for at least 4 months; ? Serum basal FSH > 25U/L at least twice (interval > 4 weeks); ? Accompanied by at least three of the following symptoms: soreness of waist and knees, hot flashes, sweating, tinnitus, poor sleep, dry eyes, vaginal dryness, dizziness, dry skin, irritability, etc. ? Those who have not taken any hormones or drugs that affect endocrine hormones in recent 3 months; ? Informed and voluntarily participated in this clinical trial, and signed the informed consent form of clinical trial.
Exclusion criteria
Exclusion criteria: (1) Ovarian dysfunction caused by organic genital lesions; (2) those with or with other endocrine diseases; (3) allergic characteristics and allergic to experimental drugs; (4) Those who do not meet the case inclusion criteria or fail to use drugs according to regulations and have poor compliance; (5) Patients with serious primary diseases and mental disorders such as heart, liver, brain, kidney and hematopoietic system; (6) Pregnant and lactating women and those who have never had sex.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Follicle Stimulating Hormone,FSH; | — |
Secondary
| Measure | Time frame |
|---|---|
| Estradiol,E2;Luteinizing Hormone,LH;Peak Systolic Velocity, PSV;End - Diastolic Velocity,EDV;Antral Follicle Coun,AFC;ovarian volume;ovarian arterial resistance index,RI;ovarian blood flow pulsation index,PI;integrals of TCM syndromes;improved Kupperman score; | — |
Countries
China
Contacts
Public ContactNi Jinxia
Dongzhimen Hospital Beijing University of Chinese Medicine
Outcome results
None listed