Moyamoya Disease
Conditions
Interventions
Dexmedetomidine Group:After the patient is admitted to the operating room and anesthesia monitoring is established, the patient will be continuously infused at a rate of 0.4µg/kg/h until the end of du
Saline Group:Patients will receive the same volume of saline in the same setting.
Sponsors
Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1) Age 18-60 years; 2) Preoperative clinical diagnosis of Moyamoya disease (type); 3) Proposed hemodialysis reconstruction for Moyamoya disease under general anesthesia; 4) ASA class I-III; 5) Agreed to participate in this study and signed an informed consent form.
Exclusion criteria
Exclusion criteria: 1) Refusal to participate in this study; 2) Emergency surgery; 3) Having had an intracranial hemorrhage within 6 weeks; 4) Preoperative severe cognitive dysfunction MMSE score =20; 5) People with contraindications to the use of dexmedetomidine (severe bradycardia, sick sinus node syndrome, degree II-III AV block); 6) History of traumatic brain injury or neurosurgery; 7) Have severe hepatic or renal impairment with ALT > 3 times the upper limit of normal and creatinine > 1.5 times the upper limit of normal; 8) Pregnant or lactating women; 9) Previous history of schizophrenia, epilepsy, Parkinson's disease or myasthenia gravis; 10) Pre-operative inability to communicate due to coma, severe dementia or speech impairment; 11) Critical illness (those with preoperative ASA classification = IV); 12) Who are currently participating in another clinical trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of delirium at 5 days postoperatively; | — |
Secondary
| Measure | Time frame |
|---|---|
| Severity of postoperative nausea and vomiting;Postoperative pain;Sleep Assessment;Pre- and postoperative NIHSS scores;Incidence of postoperative adverse cerebrovascular events (postoperative cerebral infarction, postoperative hyperperfusion syndrome and secondary epilepsy);Postoperative medications: postoperative sedation, analgesia, anticholinergics, glucocorticoids, and fluid intake and output;;Length of postoperative hospitalization and total cost of hospitalization;Perioperative complication rate at 30 days postoperatively;All-cause mortality;Postoperative survival and assessment of quality of survival; | — |
Countries
China
Contacts
Public ContactBo Jinhua
Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School
Outcome results
None listed