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Correlation between diabetes mellitus, ABCB1 gene polymorphisms and antiplatelet activity of clopidogrel

Correlation between diabetes mellitus, ABCB1 gene polymorphisms and antiplatelet activity of clopidogrel

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2400082012
Enrollment
Unknown
Registered
2024-03-19
Start date
2020-07-01
Completion date
Unknown
Last updated
2024-03-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronary atherosclerotic heart disease

Interventions

Normal Group:no
MACE Group:no

Sponsors

The Affiliated Taian City Central Hospital of Qingdao University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 90 Years

Inclusion criteria

Inclusion criteria: 1) Age > 18 years; 2) Meet the diagnostic criteria for coronary artery disease in the Diagnostic and Therapeutic Guidelines for Stable CHD; 3) CYP2C19 normal metabolic; 4) First PCI treatment; 5) Receiving oral clopidogrel (75 mg orally once a day) combined with aspirin (100 mg orally once a day) for antiplatelet treatment for 12 months, and including patients with MACE during this period; 6) Having complete case data and being followed up until the end event.

Exclusion criteria

Exclusion criteria: 1) malignant tumors; 2) Contraindications to antiplatelet therapy; 3) Bleeding disorders; 4) Severe organ insufficiency; 5) Pregnancy or lactation.

Design outcomes

Primary

MeasureTime frame
ABCB1 genotype;fasting blood glucose;MACE;

Secondary

MeasureTime frame
gender;age;history of smoking;history of drinking ;Homocysteine concentration;

Countries

China

Contacts

Public Contactzhoubo

The Affiliated Taian City Central Hospital of Qingdao University

zxyyzhou@163.com+86 135 8382 7281

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026