primary open-angle glaucoma
Conditions
Interventions
Experimental group:PCP surgery + traditional Chinese medicine
Astragalus 30g,angelica 6g,red peony 10g,earthworm 12g,chuanxiong 10g,safflower10g,peach kernel 10g,butterflybush flower 10g
The medicati
Control group : PCP surgery + placebo
Sponsors
Eye Hospital of Wenzhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 55 Years
Inclusion criteria
Inclusion criteria: (1) Patients with a diagnosis of primary open-angle glaucoma or juvenile open-angle glaucoma; Primary angle-closure glaucoma diagnostic criteria: Manifested as pathological elevated intraocular pressure [generally considered when the peak intraocular pressure exceeds 21 mmHg over 24 hours (1 mmHg = 0.133 kPa)], accompanied by glaucomatous optic nerve damage (changes in optic disc and RNFL morphology) and/or glaucomatous visual field defects. Patients should demonstrate open angles on gonioscopy, and other factors potentially causing elevated intraocular pressure must be excluded. Juvenile open-angle glaucoma diagnostic criteria: Similar to primary open-angle glaucoma, onset age between 3 and 35 years, with essentially normal angle structures, absence of other congenital anomalies or syndromes, and no ocular enlargement (2) Age between 18 and 55 years old; (3) Glaucoma patients scheduled for PCP; (4) Willing to undergo traditional Chinese medicine treatment postoperatively; (5) Signed informed consent and voluntarily participating in this study. Note: Patients who simultaneously meet all five criteria mentioned above can be included in this study.
Exclusion criteria
Exclusion criteria: 1. Patients with secondary glaucoma or glaucoma following other surgeries; 2. Patients self-administering neuroprotective drugs or traditional Chinese medicine for conditions other than using intraocular pressure-lowering medications or medications for underlying diseases (including hypertension, diabetes, etc.); 3. Poorly controlled diabetic patients or those with diabetic retinopathy; 4. Patients planning for pregnancy, pregnant, or breastfeeding; 5. Patients with a tendency for bleeding (e.g., long-term use of aspirin or anticoagulants such as warfarin, abnormal coagulation function test results exceeding normal values by two times or more); 6. Patients unable to adhere to scheduled follow-ups or unwilling to sign informed consent. Note: Patients who meet any of the criteria mentioned above should be excluded from the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of transient intraocular pressure elevation after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative follow-up of intraocular pressure;Transient peak intraocular pressure;Duration of transient intraocular pressure elevation; | — |
Countries
China
Contacts
Public ContactYuanbo Liang
Eye Hospital of Wenzhou Medical University
Outcome results
None listed