No disease involved
Conditions
Interventions
Morning group 08:00 ~ 10:00 (group A) :NA
Afternoon group 14:00-16:00 (group B):NA
Night group 21:00-23:00 (group C):NA
Sponsors
Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
Eligibility
Sex/Gender
All
Age
30 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1: Age between 30 and 60 years old (including boundary values) 2: Patients with laparoscopic cholecystectomy or laparoscopic appendectomy who meet the criteria for general anesthesia 3: BMI between 18 and 24 (including boundary values) 4: Classified as ASA grade I-II 5: The Child's grade was A 6: Volunteer to participate in the study and sign the informed consent If the subject is not capable of reading the informed consent (such as illiterate subjects), a witness should witness the informed process and sign the informed consen
Exclusion criteria
Exclusion criteria: 1: Breastfeeding and pregnancy, or planning pregnancy within 6 months 2: Patients who have performed cardiopulmonary resuscitation before and have not recovered their neurological function 3: Patients with a history of severe cardiovascular respiratory renal liver hematologic malignancies or immune diseases: heart failure greater than NYHA Grade II 4: For active myocardial ischemia, cardiovascular intervention was performed within 60 days 5: History of cirrhosis 6: Chronic kidney disease, creatinine clearance < 40 mL/min 7: Chronic obstructive pulmonary disease requiring home oxygen therapy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Drug concentration;Apparent Clearance Rate;Apparent volume of distribution;Half-life period;Area under the curve; | — |
Countries
China
Contacts
Public ContactXin Yu
Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
Outcome results
None listed