The protective effect of dexmedetomidine combined with butorphanol on perioperative lung function in patients undergoing laparoscopic resection of colorectal cancer

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2400081959

Enrollment

Unknown

Registered

2024-03-18

Start date

2024-03-18

Completion date

Unknown

Last updated

2024-03-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Lung function

Interventions

C group:Normal saline

DEX group:Dexmedetomidine

BUT group:Butorphanol

DB group:Dexmedetomidine+ Butorphanol

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Age: 18-65 2. BMI: 18.5-30kg/m2 3. ASA Level: I-III 4. Selective general anesthesia for laparoscopic resection of colorectal cancer 5. Sign informed consent form

Exclusion criteria

Exclusion criteria: 1. Severe liver and kidney dysfunction, moderate to severe anemia (Hb<90g/L) 2. Preoperative severe respiratory dysfunction (PaO2<60mmHg), FEV1/FVC<50%, severe obstructive sleep apnea syndrome (OSAS) 3. Allergies or contraindications to drugs related to this study 4. Severe mental or hearing impairment, inability to communicate normally

Design outcomes

Primary

Measure	Time frame
Arterial alveolar oxygen partial pressure ratio;	—

Secondary

Measure	Time frame
Intrapulmonary shunt;Oxygenation index;Alveolar arterial oxygen pressure difference;Dead space to tidal volume ratio;Postoperative incidence of pulmonary complications;Recovery Quality QoR-15 Rating;	—

Countries

China

Contacts

Public ContactGao Fang

The Affiliated Hospital of Xuzhou Medical University

gaofangxz@126.com+86 180 5226 8331

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026