Parkinson's disease
Conditions
Interventions
PD with chronic appendicitis/PD without chronic appendicitis:NA
Sponsors
The First Affiliated Hospital of University of Science and Technology of China
Eligibility
Sex/Gender
All
Age
30 Years to 80 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: According to the 2015 International Movement Disorder Society (MDS) diagnostic criteria (PD syndrome criteria) 1. Patients demonstrates bradykinesia with tremor, rigidity, or both. 2. All participants signed informed consent forms 3. Coagulation function is generally normal
Exclusion criteria
Exclusion criteria: Exclusion criteria: 1. Patients treatment with dopamine blockers or dopamine-depleting agents, and the doses and courses are consistent with drug-induced Parkinson's diseases; 2. Functional neuroimaging of Presynaptic dopamine is normal. 3. Suffered severe brain injury or underwent complex craniotomy within 5 years; 4. Patients diagnosed with Alzheimer's disease, frontotemporal dementia, and Niemann-Pick diseases; 5. People diagnosed with severe neuropsychiatric disorders (epilepsy, bipolar disorder, major depressive episode, etc.) according to the DSM-V; 6. Complicated with serious systemic diseases, consciousness disorders, stroke, serious coronary heart disease, diabetes, liver and kidney diseases, and serious visual and hearing disorder; 7. Patients with Severe organic or functional dysphagia; 8. Patients who were unable to complete follow-up visit and auxiliary examinations as required by the study protocol
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intestinal microorganism;imaging features of appendix ;Constipation scale;Fecal microorganisms and metabolites; | — |
Secondary
| Measure | Time frame |
|---|---|
| Unified Parkinson's Disease Rating Scale (UPDRS);Non-motor symptoms scales;Cognitive scales;Parkinson disease sleep scale; Blood pressure monitoring;Residual urine measurement;UPDRS-? score improvement of Levodopa challenge test;Related indicators of blood immune cell metabolites ;The quality of PET-CT imaging;brain MRI data; | — |
Countries
China
Contacts
Public ContactChen Yuhua
The First Affiliated Hospital of University of Science and Technology of China
Outcome results
None listed