colorectal cancer
Conditions
Interventions
LOA group (Less opioid anesthesia group):LOA group was given dexmedetomidine 0.6µg/kg at a constant rate 10min before anesthesia induction. Induction period of anesthesia: LOA group: remazolam: 0.2mg/
Propofol: 1-2mg/kg
Atracurium cisenesulfonate 0.2mg/kg, Sufentanil 0.2ug/kg, esketamine 0.2mg/kg. Anesthetic maintenance period: LOA group: propofol 4-6mg/kg/h, dexmedetomidine 0.1-0.2ug/kg/h, esketamine 0.2-0.3mg/kg/h.
C group:Group C: Remazolam: 0.2mg/kg
Propofol 1-2mg/kg, atracurium cisenesulfonate 0.2mg/kg, Sufentanil 0.4ug/kg. After the muscle relaxant took effect, a tracheal catheter was inserted, ventilation was maintained by the anesthesia machi
Sponsors
First People's Hospital of Lianyungang City, Jiangsu Province
Eligibility
Sex/Gender
All
Age
40 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Patients undergoing elective endoscopic colorectal resection; 2. American Association of Anesthesiologists (ASA) patient grade I to II; 3. Age 40~70 years old; 4. Patients were informed of the main test methods and possible adverse reactions, and signed informed consent; 5. Heart, lung, liver, kidney and coagulation function were not abnormal; 6. The patient requested the use of self-controlled analgesia devices after surgery.
Exclusion criteria
Exclusion criteria: 1. ASA? level or above; 2. A history of allergy to or contraindication to ropivacaine, esketamine, or nonsteroidal anti-inflammatory drugs (NSAID) (serious risk of elevated blood pressure and intracranial pressure, poorly controlled or untreated hypertension, untreated or undertreated hyperthyroidism, gastrointestinal bleeding); 3. Have mental illness and other chronic pain or other conditions that may confuse the analgesic response; 4. Can not read and write Chinese, communication barriers; 5. Patients with severe heart disease and respiratory disease; 6. Patients with serious skin damage and infection in the ultrasound scan area; 7. Unwillingness to use intravenous pain relief pumps and refusal to participate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Quality of recovery scores-15; | — |
Secondary
| Measure | Time frame |
|---|---|
| Quality of recovery scores-15;Visual Analogue Scale (VAS);Intraoperative hemodynamic indexes;Perioperative adverse reactions;Duration of stay in anesthesia recovery room;Intraoperative sufentanil usage;Sufentanil usage after surgery; | — |
Countries
China
Contacts
Public ContactHengfei Luan
First People's Hospital of Lianyungang City, Jiangsu Province
Outcome results
None listed