Sarcopenia
Conditions
Interventions
Individual Vitamin K2 Intervention group (Study Plan 2):Daily Vitamin K2 200ug
Vitamin K2+Vitamin D combined intervention group (Study Plan 2):Daily Vitamin K2 200ug+Vitamin D1000IU
Individual vitamin D intervention group (Study Plan 2):Daily Vitamin D1000IU
Control group (Study Plan 2):Conduct nutrition education and consultation, and introduce specific food intake standards to participants using a food model.
Cross-sectional epidemiological survey:None
Sponsors
Peking Union Medical College Hospital (PUMCH)
Eligibility
Sex/Gender
All
Age
No minimum to 100 Years
Inclusion criteria
Inclusion criteria: Research Plan 1: Age 18 and above; Having communication and cognitive abilities; Agree to participate in this experiment. Research Plan 2: a) Gender unlimited; b) Age>65 years old; c) Han ethnicity; d) Meets the diagnostic criteria for muscle atrophy; e) Having communication and cognitive abilities; f) Sign an informed consent form and voluntarily participate in this study.
Exclusion criteria
Exclusion criteria: Research Plan 1: Suffering from heart disease, liver and kidney dysfunction, immune system diseases, acute attacks of chronic diseases, infectious diseases, etc; Lack of autonomous activity ability; Implantation of electronic devices or metal objects into the body; Lack of communication and cognitive abilities; Disagree to participate in this study. Study Plan 2: (a) Hepatorenal insufficiency (Child Pugh grades 2 and 3, GFR7.0%, and diabetes nephropathy has been in stage 4 or above; c) Immune system diseases, neurodegenerative diseases, infectious diseases, Sjogren's syndrome, malignant tumors, and metabolic diseases such as chronic obstructive pulmonary disease; d) Implantation of electronic devices or metal objects into the body; e) Supplemented with protein fortified foods, fish oil, vitamin D, vitamin K2, etc. within the first three months of the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Muscle mass (Study Plan 2);Muscle Strength (Research Plan 2);The nutritional status of vitamin K2 in different age groups (adult and elderly) and its relationship with muscle atrophy (Study Plan 1); | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum Vitamin K2 (Study Plan 2);Serum Vitamin D3 (Study Plan 2);Fasting insulin (Study Plan 2);Serum inflammatory factors (TWEAK, TNF) a IL-6 and leptin, etc. (Study Plan 2);Quality of Life Score (Study Plan 2);Clinical outcomes and related complications (such as fractures, frailty, and infectious complications) (Study Plan 2);Serum Vitamin K2 (Study Plan 1);Serum Vitamin D3 (Study Plan 1);Blood glucose (Study Plan 1);Blood lipids (Study Plan 1);Insulin (Study Plan 1);Liver and kidney function (research plan one);nflammatory indicators, etc. (Research Plan 1); | — |
Countries
China
Contacts
Public ContactYu Kang
Peking Union Medical College Hospital (PUMCH)
Outcome results
None listed