Joint replacement
Conditions
Interventions
Grouping based on whether postoperative chronic pain occurs:None
Sponsors
The Affiliated Hospital of Xuzhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) Age 18-80 years old, gender is not limited; (2) American Society of Anesthesiologists (ASA) Grade I to III; (3) BMI 18.5 ~ 30 kg/m2; (4) Patients undergoing unilateral lower limb joint replacement under elective general anesthesia; (5) Patients and their families give informed consent and sign informed consent.
Exclusion criteria
Exclusion criteria: (1) Previous history of lower extremity joint surgery; (2) Have a history of allergy to analgesic drugs or drug addiction; (3) Previous history of cerebral hemorrhage and cerebral infarction; (4) Rheumatoid arthritis, systemic lupus erythematosus and other rheumatic immune system diseases; (5) Preoperative complicated with severe heart, brain and lung disease or abnormal liver and kidney function; (6) Chronic diseases such as chronic obstructive pulmonary disease and asthma; A history of taking antidepressants or sedatives during the follow-up period; (7) Concurrent with other active infections on admission or any other inflammation and medical complications during hospitalization; (8) Patients undergoing emergency trauma surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of chronic pain at 3 months (90 days) after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Neutrophil to lymphocyte ratio;Platelet to lymphocyte ratio;Systemic immune inflammatory index; | — |
Countries
China
Contacts
Public ContactShen Wen
The Affiliated Hospital of Xuzhou Medical University
Outcome results
None listed